In a phase 3 trial, patients with prostate cancer with high-risk biochemical recurrence showed better outcomes with enzalutamide treatments vs leuprolide monotherapy with respect to metastasis-free survival. Both enzalutamide plus leuprolide and enzalutamide monotherapy significantly improved 5-year metastasis-free survival rates (87.3% and 80.0%, respectively) compared with 71.4% with leuprolide alone. The study concludes that enzalutamide, alone or with leuprolide, is superior to leuprolide alone in patients with prostate cancer and high-risk biochemical recurrence.

Reference: Freedland SJ, de Almeida Luz M, De Giorgi U, et al. Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer. N Engl J Med. 2023;389(16):1453-1465. doi:10.1056/NEJMoa2303974

Care guidelines from NCI and NCCN for adolescents and young adults (AYAs) with cancer propose a model addressing patient-level (eg, socio-economic status, treatment) and system-level factors (eg, clinical trial access, support) to confront the unique challenges AYAs with cancer face. These challenges include lower survival improvements and developmental issues impacting their healthcare cancer outcomes. The guidelines emphasize the need for comprehensive interventions to enhance clinical and quality of life outcomes.

Reference: Wolfson JA, Kenzik KM, Foxworthy B, et al. Understanding Causes of Inferior Outcomes in Adolescents and Young Adults With Cancer. J Natl Compr Canc Netw. 2023;21(8):881-888. doi:10.6004/jnccn.2023.7056 

A review of fertility preservation interventions for women cancer survivors found nine interventions aligning variably with ASCO guidelines and a multilevel framework. Most interventions referred patients to reproductive specialists, with limited focus on psychosocial services. Only five interventions considered stakeholder perspectives, and few discussed sustainability. The review highlights gaps in fertility preservation practices, suggesting updates to clinical guidelines and multilevel framework integration for improvement.

Reference: Pathak S, Vadaparampil ST, Sutter ME, Rice WS, McBride CM. Evaluating fertility preservation interventions for alignment with ASCO Guidelines for reproductive aged women undergoing cancer treatment: a systematic review. Support Care Cancer. 2023;31(12):689. doi:10.1007/s00520-023-08133-3